Experimental Rickets

Experimental Rickets in Rats

1. Rachitic bone lesions may be produced in rats by a diet containing an excess of calcium, but deficient in phosphates. 2. Similar lesions follow a diet deficient in calcium, but containing an excess of phosphates. The endochondral lesions, however, are less pronounced. 3. A diet deficient in both calcium and phosphate induces atypical rickets. 4. Inorganic salts other than calcium or phosphat...

Experimental Rickets in Rabbits

Rickets has been produced experimentally in rabbits by the administration of diets deficient in the antirachitic organic factor and phosphorus but with a high calcium content. Cod liver oil added to these rickets-producing diets prevented the development of rickets in rabbits.

Studies on Experimental Rickets

Our observations show that young rabbits born of mothers afflicted with Schistosomum japonicum develop typical rickets. Rickets can also be produced if we infect the young, healthy rabbits with the same parasite. It is natural to suppose that the rachitic changes are caused by the parasite itself. Since, however, a similar disease can be produced in the offspring, when the mother is fed on egg ...

Rickets

Nutritional Rickets

Nutritional rickets (NR) is still the most common form of growing bone disease despite the efforts of health care providers to reduce the incidence of the disease. Today, it is well known that the etiology of NR ranges from isolated vitamin D deficiency (VDD) to isolated calcium deficiency. In Turkey, almost all NR cases result from VDD. Recent evidence suggests that in addition to its short- o...